孙佳姝课题组
孙佳姝课题组
Jiashu Sun, obtained her B. S. at Beijing Institute of Technology (2006), followed by a Ph. D. (2010) from Vanderbilt University, working on microfluidics and single cell analysis. She joined the National Center for Nanoscience and Technology (NCNST) as Assistant Professor in 2011 and was promoted to Full Professor/Principal Investigator in 2016. Jiashu’s research interests include microfluidics for liquid biopsy, microfluidic synthesis, and nanomedicine. She has authored more than 70 peer-reviewed papers in leading international journals inlcuding Nature Biomedical Engineering, Nature Communications, Chemical Society Reviews, Journal of the American Chemical Society, Advanced Materials, Angewandte Chemie International Edition, ACS Nano, Nano Letters, Analytical Chemistry, Lab on a Chip, etc.
Research field:
1. Isolation and analysis of extracellular vesicles
Extracellular vesicles are double-layered vesicles secreted by cells, with a diameter of about 200-2000 nm, and are widely present in biological fluids such as blood and urine. Extracellular vesicles are loaded with different biological macromolecules, including DNA, RNA, protein, lipid, etc., and can be used as biomarkers for disease diagnosis. However, the components of serum are complex, and the efficient separation and analysis of extracellular vesicles is still challenging. Our group propose a microfluidic platform for label-free, high-resolution and rapid separation of three different subsets of extracellular vesicles (exosomes, microvesicles and apoptotic bodies) based on interface effects. Our group also combine thermophoretic technology and fluorescent DNA probes to achieve efficient and selective enrichment of extracellular vesicles from body fluid samples. With laser irradiation, a temperature gradient is formed in the microcavity, and extracellular vesicles with larger size can be enriched by thermophoresis, while proteins with smaller size and excess fluorescent probes remain free. By capturing fluorescent signals, proteins and nucleic acids carried by extracellular vesicles can be quantified. This thermophoretic platform can be used for early cancer screening, staging and recurrence monitoring.
2. Isolation and analysis of circulating tumor cells
Circulating tumor cells are cells that shed from tumor tissue and exist in the blood circulation. Circulating tumor cells are closely related to tumor recurrence and metastasis, and are important biomarkers for liquid biopsy. However, compared with blood cells, circulating tumor cells are quite rare, making the separation and detection of circulating tumor cells facing great challenges. Our group develop an interface effect-based microfluidic platform to achieve high efficiency (97.1%), high recovery (76.3%), and label-free separation of rare tumor cells from whole blood sample.
3. Point-of-care molecular diagnosis
Molecular diagnosis is the diagnostic method with the genetic material as the target. PCR and its derivative technologies rely on central laboratories and trained technicians, and cannot perform rapid point-of-care testing in communities, rural areas, and suburban areas. Our group reported that the loop-mediated isothermal amplification-based disk microfluidic chip for on-site molecular diagnosis. The chip can achieve nucleic acid purification, amplification, and detection, and does not require an external electrical power supply. This microfluidic chip can achieve rapid point-of-care detection of pathogens at resource-limited setting.
4. Precise construction of nanometer functional materials
The structure of nanomaterials can greatly affect their properties. Our group develop several microfluidic platforms to achieve efficient synthesis of nanomaterials with controllable structure and property. In a three-dimensional heterogeneous microcavity array, a high-speed rotating chiral laminar flow microvortex is used to precisely control the co-assembly of amino acid racemate and achiral porphyrin molecules. Within a few milliseconds, a supramolecular seed with determined chirality is formed and the seed continues to induce assembly to form a supramolecular structure. By measuring the CD signal of supramolecular structure, sensitive and quantitative detection of racemates and enantiomers of amino acids can be achieved. Our group also build a multistage microfluidic platform for high-throughput synthesis of monodisperse core-shell carrier particles with controllable particle size and structure, which can achieve targeted tumor therapy.
Publications
2023
102. Li, Zhenglin#; Liu, Chao#; Sun, Jiashu*; Hydraulic-electric analogy for design and operation of microfluidic systems. Lab on a Chip, 2023, 23, 3313-3327.
101. Zhao, Shuai#; Zhang, Shaohua#; Hu, Huijun#; Cheng, Yangchang; Zou, Kexuan; Song, Jie; Deng, Jinqi*; Li, Lele; Zhang, Xiao-Bing; Ke, Guoliang*; Sun, Jiashu*; Selective in situ analysis of mature microRNAs in extracellular vesicles using a DNA cage-based thermophoretic assay. Angewandte Chemie International Edition, 2023, 62, 202303121.
100. Li, Zhenglin#; Liu, Chao#; Cheng, Yangchang#; Li, Yike; Deng, Jinqi; Bai, Lixiao; Qin, Lili; Mei, Huili; Zeng, Min; Tian, Fei*; Zhang, Shaohua*; Sun, Jiashu*; Cascaded microfluidic circuits for pulsatile filtration of extracellular vesicles from whole blood for early cancer diagnosis. Science Advances, 2023, 9, eade2819.
99. Cheng, Yangchang#; Zhang, Shaohua#; Qin, Lili; Zhao, Junxiang; Song, Hua; Yuan, Yang; Sun, Jiashu; Tian, Fei*; Liu, Chao*; Poly(ethylene oxide) concentration gradient-based microfluidic isolation of circulating tumor cells. Analytical Chemistry 2023, 95, 3468-3475.
2022
98. Zhang, Shaohua#; Deng, Jinqi#; Li, Jianbin; Tian, Fei; Liu, Chao*; Fang Luo*; Sun, Jiashu*; Advanced microfluidic technologies for isolating extracellular vesicles. Trends in Analytical Chemistry 2022, 157, 116817.
97. Deng, Jinqi#; Zhao, Shuai#; Li, Junhong#; Cheng, Yangchang; Liu, Chao; Liu, Zheng; Li, Lele; Tian, Fei*; Dai, Bo*; Sun, Jiashu*; One-step thermophoretic AND gate operation on extracellular vesicles improves diagnosis of prostate cancer. Angewandte Chemie International Edition 2022, 61, 202207037.
96. Tian, Fei#; Liu, Chao#; Deng, Jinqi; Sun, Jiashu*; Microfluidic separation, detection, and engineering of extracellular vesicles for cancer diagnostics and drug delivery. Accounts of Materials Research 2022, 3, 498-510.
95. Liu, Ruochen; Yang, Wenming; Xu, Wanzhen*; Deng, Junyang; Ding Chenming; Guo Yifu; Zheng Lei; Sun, Jiashu*; Li, Mengmeng*; Impact of chemical design on molecular orientation of conjugated donor-acceptor polymers for field-effect transistors. ACS Applied Polymer Materials 2022, 4, 2233-2250.
94. Tian, Fei#; Cai Lili#; Liu, Chao*; Sun, Jiashu*; Microfluidic technologies for nanoparticle formation. Lab on a Chip 2022, 22, 512-529.
93. Liu, Chao#; Tian, Fei#; Deng, Jinqi; Sun, Jiashu*; Thermomicrofluidic biosensing systems. Acta Chimica Sinica 2022, 80, 679-689.
2021
92. Tian, Fei#; Zhang, Shaohua#; Liu, Chao*; Han, Ziwei; Liu, Yuan; Deng, Jinqi; Li, Yike; Wu, Xia; Cai, Lili; Qin, Lili; Chen, Qinghua, Yuan, Yang; Liu, Yi; Cong, Yulong; Ding, Baoquan; Jiang, Zefei*; Sun, Jiashu*; Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer. Nature Communications 2021, 12, 2536.
91. Deng, Jinqi#; Tian, Fei#; Liu, Chao*; Liu, Yuan; Zhao, Shuai; Fu, Ting; Sun, Jiashu*; Tan, Weihong*; Rapid One-Step Detection of Viral Particles Using an Aptamer-Based Thermophoretic Assay. Journal of the American Chemical Society 2021, 143, 7261-7266.
90. Han, Ziwei#; Wan, Fangning#; Deng, Jinqi#; Zhao, Junxiang; Li, Yike; Yang, Yunjie; Jiang, Qiao; Ding, Baoquan; Liu, Chao*; Dai, Bo*; Sun, Jiashu*; Ultrasensitive Detection of mRNA in Extracellular Vesicles Using DNA Tetrahedron-Based Thermophoretic Assay. Nano Today 2021, 38, 101203.
89. Li, Yike#; Deng, Jinqi#; Han, Ziwei; Liu, Chao; Tian, Fei; Xu, Rui; Han, Da*; Zhang, Shaohua*; Sun, Jiashu*; Molecular Identification of Tumor-Derived Extracellular Vesicles using Thermophoresis-Mediated DNA Computation. Journal of the American Chemical Society 2021, 143, 1290-1295.
88. Tian, Fei#; Han, Ziwei#; Deng, Jinqi; Liu, Chao*; Sun, Jiashu*; Thermomicrofluidics for biosensing applications. View 2021, 2, 20200148.
87. Liu, Yuan; Deng, Jinqi; Zhao, Shuai; Tian, Fei*; Li, Yi*; Sun, Jiashu; Liu, Chao*; Lateral flow assay based on molecular recognition for diagnosis of Corona Virus Disease 2019 infection. Chemical Journal of Chinese Univeristies 2021, 11, 3390-3405.
86. Liu, Chao; Sun, Jiashu*; AI in Measurement Science. Annual Review of Analytical Chemistry 2021, 14, 1–19.
85. Deng, Jinqi#; Zhao, Shuai#; Liu, Yuan; Liu, Chao; Sun, Jiashu*; Nanosensors for diagnosis of infectious diseases. ACS Applied Bio Materials 2021, 4, 3863–3879.
84. Zhao, Shuai#; Tian, Run#; Wu, Jun#; Liu, Shaoli; Wang, Yuanning; Wen, Meng; Shang, Yingxu; Liu, Qing; Li, Yan; Guo, Ying; Wang, Zhaoran; Wang, Ting; Zhao, Yujing; Zhao, Huiru; Cao, Hui; Su, Yu; Sun, Jiashu; Jiang, Qiao*; Ding, Baoquan*; A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis. Nature Communications 2021, 12, 358.
83. Wang, Zhaoran#; Song, Linlin#; Liu, Qing#; Tian, Run; Shang, Yingxu; Liu, Fengsong; Liu, Shaoli; Zhao, Shuai; Han, Zihong; Sun, Jiashu; Jiang, Qiao*; Ding, Baoquan*; A tubular DNA nanodevice as a siRNA/chemo-drug co-delivery vehicle for combined cancer therapy. Angewandte Chemie International Edition 2021, 60, 2594-2598.
82. Chang, Jianqiao#; Zhang, Yu#; Li, Yike; Han, Ziwei; Tian, Fei; Liu, Chao; Feng, Qiang*; Wang, Yuguang*; Sun, Jiashu; Zhang, Lu*; Multilayer Ratiometric Fluorescent Nanomachines for Imaging mRNA in Live Cells. Small Methods 2021, 5, 2001047.
81. Zhao, Yongxi#; Zuo, Xiaolei#; Li, Qian#; Chen, Feng; Chen, Yan-Ru; Deng, Jinqi; Han, Da; Hao, Changlong; Huang, Fujian; Huang, Yanyi; Ke, Guoliang; Kuang, Hua; Li, Fan; Li, Jiang; Li, Min; Li, Na; Lin, Zhenyu; Liu, Dingbin; Liu, Juewen; Liu, Libing; Liu, Xiaoguo; Lu, Chunhua; Luo, Fang; Mao, Xiuhai; Sun, Jiashu; Tang, Bo; Wang, Fei; Wang, Jianbin; Wang, Lihua; Wang, Shu; Wu, Lingling; Wu, Zai-Sheng; Xia, Fan; Xu, Chuanlai; Yang, Yang; Yuan, Bi-Feng; Yuan, Quan; Zhang, Chao; Zhu, Zhi; Yang, Chaoyong*; Zhang, Xiao-Bing*; Yang, Huanghao*; Tan, Weihong*; Fan, Chunhai*; Nucleic Acids Analysis. Science China Chemistry 2021, 64, 171–203.
80. Lv, Wenxing#; Han, Ziwei#; Li, Yike; Huang, Yanjuan; Sun, Jiashu; Lu, Xiaoquan*; Liu, Chao*; Exosome-Coated Zeolitic Imidazolate Framework Nanoparticles for Intracellular Detection of ATP. Chinese Journal of Chemistry 2021, 39, 2107–2112.
2020
79. Liu, Fengsong#; Jiang, Qiao#; Liu, Qing; Li, Na; Han, Zihong; Liu, Chao; Wang, Zhaoran; Jiao, Yunfei; Sun, Jiashu; Ding, Baoquan*; Logic gated plasmonic nanodevices based on DNA-templated assembly. CCS Chemistry 2020, 2, 985-993.
78. Tian, Fei#; Liu, Chao#; Deng, Jinqi; Han, Ziwei; Zhang, Lu*; Chen, Qinghua*; Sun, Jiashu*; A Fully Automated Centrifugal Microfluidic System for Sample-to-Answer Viral Nucleic Acid Testing. Science China Chemistry 2020, 63, 1498–1506.
77. Zhao, Junxiang#; Liu, Chao#; Li, Yike; Ma, Yao; Deng, Jinqi; Li, Lele; Sun, Jiashu*; Thermophoretic Detection of Exosomal microRNAs by Nanoflares. Journal of the American Chemical Society 2020, 142, 4996-5001.
76. Li, Yike#; Liu, Chao#; Bai, Xuan#; Tian, Fei; Hu, Guoqing; Sun, Jiashu*; Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by using Achiral Building Blocks. Angewandte Chemie International Edition 2020, 59, 3486-3490.
75. Lin, Ling; Yi, Linglu; Zhao, Fanghao; Wu, Zengnan; Zheng, Yajing; Li, Nan; Lin, Jin-Ming*; Sun, Jiashu*; ATP-responsive Mitochondrial Probes for Monitoring Metabolic Processes of Glioma Stem Cells in a 3D Model. Chemical Science 2020, 11, 2744-2749.
74. Zhang, Lu; Chen, Qinghua; Ma, Yao; Sun, Jiashu*; Microfluidic Methods for Fabrication and Engineering of Nanoparticle Drug Delivery Systems. ACS Applied Bio Materials 2020, 3, 107-120.
73. Han, Ziwei; Lv, Wenxing; Li, Yike; Chang, Jianqiao; Zhang, Wei; Liu, Chao; Sun, Jiashu*; Improving Tumor Targeting of Exosomal Membrane-Coated Polymeric Nanoparticles by Conjugation with Aptamers. ACS Applied Bio Materials 2020, 3, 2666-2673.
2019
72. Liu, Chao#; Zhao, Junxiang#; Tian, Fei; Cai, Lili; Zhang, Wei; Feng, Qiang; Chang, Jianqiao; Wan, Fangning; Yang, Yunjie; Dai, Bo; Cong, Yulong; Ding, Baoquan; Sun, Jiashu*; Tan, Weihong; Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers. Nature Biomedical Engineering 2019, 3, 183-193.
71. Liu, Chao; Zhao, Junxiang; Tian, Fei; Chang, Jianqiao; Zhang, Wei; Sun, Jiashu*; λ-DNA- and Aptamer-Mediated Sorting and Analysis of Extracellular Vesicles. Journal of the American Chemical Society 2019, 141, 3817-3821.
70. Liu, Chao#; Feng, Qiang#; Sun, Jiashu*; Lipid nanovesicles by microfluidics: manipulation, synthesis and drug delivery. Advanced Materials 2019, 31, 1804788.
69. Liu, Chao; Zhang, Wei; Li, Yike; Chang, Jianqiao; Tian, Fei; Zhao, Fanghao; Ma, Yao; Sun, Jiashu*; Microfluidic Sonication to Assemble Exosome Membrane-Coated Nanoparticles for Immune Evasion-Mediated Targeting. Nano Letters 2019, 19, 7836-7844.
68. Tian, Fei#; Liu, Chao#; Lin, Ling#; Chen, Qinghua; Sun, Jiashu*; Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles. Trends in Analytical Chemistry 2019, 117, 128-145.
67. Tian, Fei; Feng, Qiang; Chen, Qinghua; Liu, Chao*; Li, Tiejun*; Sun, Jiashu*; Manipulation of bio-micro/nanoparticles in non-Newtonian microflows. Microfluidics and Nanofluidics 2019, 23, 68.
66. Ryu, Ji Young#; Kim, Jihye#; Shon, Min Ju#; Sun, Jiashu; Jiang, Xingyu; Lee, Wonhee*; Yoon, Tae-Young*; Profiling protein-protein interactions for single cancer cells with in situ lysis and co-immunoprecipitation. Lab on a Chip 2019, 19, 1922-1928.
2018
65. Sun, Jiashu#*; Li, Yike#; Yan, Fusheng#; Liu, Chao#; Sang, Yutao; Tian, Fei; Feng, Qiang; Duan, Pengfei; Zhang, Li; Shi, Xinghua; Ding, Baoquan*; Liu, Minghua*; Control over the emerging chirality in supramolecular gels and solutions by chiral microvortices in milliseconds. Nature Communications 2018, 9, 2599.
64. Lin, Ling; Chen, Qinghua; Sun, Jiashu*; Micro/nanofluidics-enabled single-cell biochemical analysis. Trends in Analytical Chemistry 2018, 99, 66-74.
63. Zhang, Lu#*; Tian, Fei#; Liu, Chao; Feng, Qiang; Ma, Tingxuan; Zhao, Zishan; Li, Tiejun; Jiang, Xingyu*; Sun, Jiashu*; Hand-powered Centrifugal Microfluidic Platforms Inspired by a Spinning Top for Sample-to-Answer Diagnostics of Nucleic Acids. Lab on a Chip 2018, 18, 610-619.
62. Tian, Fei#; Cai, Lili#; Chang, Jianqiao; Li, Shanshan; Liu, Chao*; Li, Tiejun*; Sun, Jiashu*; Label-Free Isolation of Rare Tumor Cells from Untreated Whole Blood by Interfacial Viscoelastic Microfluidics. Lab on a Chip 2018, 18, 3436-3445.
61. Lin, Ling*; Li, Yu; Khan, Mashooq; Sun, Jiashu; Lin, Jin-Ming*; Real-time characterization of negative air ions-induced decomposition of indoor organic contaminants by mass spectrometry. Chemical Communications 2018, 54, 10687-10690.
2017
60. Liu, Chao; Guo, Jiayi; Tian, Fei; Yang, Na; Yan, Fusheng; Ding, Yanping; Wei, JingYan; Hu, Guoqing*; Nie, Guangjun*; Sun, Jiashu*; Field-free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows. ACS Nano 2017, 11, 6968-6976.
59. Jiang, Qiao#; Liu, Qing#; Shi, Yuefeng#; Wang, Zhen-Gang; Zhan, Pengfei; Liu, Jianbing; Liu, Chao; Wang, Hui; Shi, Xinghua; Zhang, Li; Sun, Jiashu*; Ding, Baoquan*; Liu, Minghua*; Stimulus-Responsive Plasmonic Chiral Signals of Gold Nanorods Organized on DNA Origami. Nano Letters 2017, 17, 7125-7130.
58. Feng, Qiang#; Liu, Jianping#; Li, Xuanyu; Chen, Qinghua; Sun, Jiashu*; Shi, Xinghua; Ding, Baoquan; Yu, Haijun*; Li, Yaping; Jiang, Xingyu*; One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid- Switchable Surface Charge for Overcoming Drug Resistance. Small 2017, 13, 1603109, Back Cover.
57. Zhang, Lu#; Ding, Baozhi#; Chen, Qinghua#; Feng, Qiang; Lin, Ling*; Sun, Jiashu*; Point-of-Care-Testing of Nucleic Acids by Microfluidics. Trends in Analytical Chemistry 2017, 94, 106-116.
56. Tian, Fei; Zhang, Wei; Cai, Lili; Li, Shanshan; Hu, Guoqing; Cong, Yulong; Liu, Chao*; Li, Tiejun*; Sun, Jiashu*; Microfluidic Co-flow of Newtonian and Viscoelastic Fluids for High-resolution Separation of Microparticles. Lab on a Chip. 2017, 17, 3078-3085, HOT papers (top 10 % of papers).
55. Hu, Binfeng; Li, Juanjuan; Mou, Lei; Liu, Yong; Deng, Jinqi; Qian, Wei; Sun, Jiashu*; Cha, Ruitao*; Jiang, Xingyu*; An Automated and Portable Microfluidic Chemiluminescent Immunoassay for Quantitative Detection of Biomarkers. Lab on a Chip. 2017, 17, 2225-2234.
54. Lin, Ling#; Lin, Xuexia#; Lin, Luyao; Feng, Qiang; Kitamori, Takehiko; Lin, Jin-Ming*; Sun, Jiashu*; Integrated Microfluidic Platform with Multiple Functions to Probe the Tumor-endothelial Cell Interaction. Analytical Chemistry 2017, 89, 10037-10044.
53. Chen, Yiping#; Xianyu, Yunlei#; Wu, Jing#; Dong, Mingling; Zheng, Wenshu; Sun, Jiashu*; Jiang, Xingyu*; Double Enzymes-mediated Bioluminescent Sensor for Quantitative and Ultra-sensitive Point-of-care Testing. Analytical Chemistry 2017, 89, 5422-5427.
52. Wu, Jing#; Chen, Yiping#,*; Yang, Mingzhu; Wang, Yu; Zhang Cheng; Yang, Mo; Sun, Jiashu*; Xie, Meng-Xia*; Jiang, Xingyu*; Streptavidin-Biotin-Peroxidase Nanocomplex-Amplified Microfluidics Immunoassays for Simultaneous Detection of Inflammatory Biomarkers. Analytica Chimica Acta 2017, 982, 138-147.
51. Lin, Ling; Lai, Meishuang; Li, Haifang; Tian, Fei; Chen, Yulong*; Sun, Jiashu*; Lin, Jin-Ming*; Investigation of Carbon Deposition Induced by Pyrolytic Decomposition of Ethylene. RSC Advances 2017, 7, 29639-29644.
50. Sun, Jiashu; Yang, Juekuan; Gao, Yandong; Xu, Dongyan; Li, Deyu*; Reference Channel-based Microfluidic Resistance Sensing For Single Yeast Cell Volume Growth measurement. Microfluidics and Nanofluidics 2017, 21, 33.
2016
49. Wang, Shiwen; Feng, Qiang; Sun, Jiashu*; Gao, Feng; Fan, Wei; Zhang, Zhong; Li, Xiaohong*; Jiang, Xingyu*; Nanocrystalline Cellulose Improves the Biocompatibility and Reduces the Wear Debris of Ultrahigh Molecular Weight Polyethylene via Weak Binding. ACS Nano 2016, 10, 298-306.
48. Lu, Wenjing#; Chen, Yiping#; Liu, Zhong#; Tang, Wenbo; Feng, Qiang; Sun, Jiashu*; Jiang, Xingyu*; Quantitative Detection of MicroRNA in One Step via Next Generation Magnetic Relaxation Switch Sensing. ACS Nano 2016, 10, 6685-92.
47. Zhang, Lu; Sun, Jiashu*; Wang, Yilian; Wang, Jiancheng; Shi, Xinghua; Hu, Guoqing; A Non-specific Organelle-targeting Strategy with Core-Shell Nano-particles of Varied Lipid Components/Ratios. Analytical Chemistry 2016, 88, 7344-7351.
46. Liu, Chao; Ding, Baoquan; Xue, Chundong; Tian, Yu; Hu, Guqing*; Sun, Jiashu*, Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning. Analytical Chemistry 2016, 88, 12547-12553.
45. Feng, Qiang; Sun, Jiashu*; Jiang, Xingyu*; Microfluidics-mediated Assembly of Functional Nanoparticles for Cancer-related Pharmaceutical Applications. Nanoscale 2016, 8, 12430-12443.
44. Chen, Yiping#; Sun, Jiashu#; Xianyu, Yunlei#; Yin, Bingfeng; Niu, Yajing; Wang, Shiwen; Cao, Fengjing; Zhang, Xiaoqing; Wang, Yu; Jiang, Xingyu*; A Dual-readout Chemiluminescent Gold Lateral Flow Test for Multiplex and Ultrasensitive Detection of Disease Biomarkers in Real Samples. Nanoscale 2016, 8, 15205-15212.
43. Lu, Wenjing#; Wang, Jidong#; Wu, Qiong#; Sun, Jiashu*; Chen, Yiping; Zhang, Lu; Zheng, Chunsheng; Gao, Wenna; Liu, Yi*; Jiang, Xingyu*; High-throughput Sample-to-answer Detection of DNA/RNA in Crude Samples within Functionalized Micro-pipette Tips. Biosensors and Bioelectronics 2016, 75, 28-33.
42. Wang, Shiwen; Sun, Jiashu*; Jia, Yuexiao; Yang, Lu; Wang, Nuoxin; Xianyu, Yunlei; Chen, Wenwen; Li, Xiaohong*; Cha, Ruitao; Jiang, Xingyu*; Nanocrystalline Cellulose-Assisted Generation of Silver Nanoparticles for Non-enzymatic Glucose Detection and Antibacterial Agent. Biomacromolecules 2016, 17, 2472-2478.
41. Wang, Huashan#; Li, Juanjuan#; Zhang, Xiaoqing#; Hu, Binfeng#; Liu, Yang; Zhang Lin; Cha, Ruitao*; Sun, Jiashu*; Jiang, Xingyu*; A Microfluidic Indirect Competitive Immunoassay for Multiple and Sensitive Detection of Testosterone in Serum and Urine. Analyst 2016, 141, 815-819.
40. Yu, Miaorong#; Wang, Jiuling#; Yang, Yiwei#; Zhu, Chunliu; Su, Qian; Guo, Shiyan; Sun, Jiashu, Gan, Yong*; Shi, Xinghua*; Gao, Huajian*; Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues. Nano Letters 2016, 16, 7176–7182.
39. Chen, Yiping#; Xianyu, Yunlei#; Sun, Jiashu; Niu, Yajing; Wang Yu; Jiang, Xingyu*; One-step Detection of Pathogens and Cancer Biomarkers by Naked Eyes Based on Aggregation of Immunomagnetic Beads. Nanoscale 2016, 8, 1100-1107.
38. Liu, Chao; Xue, Chundong; Sun, Jiashu; Hu, Guqing*; A Generalized Formula for Inertial Lift on a Sphere in Microchannels. Lab on a Chip 2016, 16, 884-892.
37. Li, Juanjuan#; Liu, Yang#; Cha, Ruitao*; Ran, Bei; Mou, Kaiwen; Wang, Huashan; Xie, Qian*; Sun, Jiashu; Jiang, Xingyu*; The Biocompatibility Evaluation of Iron Oxide Nanoparticles Synthesized by a One Pot Process for Intravenous Iron Supply. RSC Advances 2016, 6, 14329-14334.
2015
36. Zhang, Lu#; Feng, Qiang#; Wang, Jiuling; Sun, Jiashu*; Shi, Xinghua; Jiang, Xingyu*; Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery. Angewandte Chemie International Edition 2015, 54 (13), 3952-6, Inside Cover.
35. Sun, Jiashu#; Zhang, Lu#; Wang, Jiuling#; Feng, Qiang; Liu, Dingbin; Yin, Qifang; Xu, Dongyan; Wei, Yujie; Ding, Baoquan; Shi, Xinghua*; Jiang, Xingyu*; Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake. Advanced Materials 2015, 27 (8), 1402-7.
34. Zhang, Lu#; Feng, Qiang#; Wang, Jiuling#; Zhang, Shuai; Ding, Baoquan; Wei, Yujie; Dong, Mingdong; Ryu, Ji-Young; Yoon, Tae-Young; Shi, Xinghua*; Sun, Jiashu*; Jiang, Xingyu*; Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell Nanoparticle Interaction. ACS Nano 2015, 9 (10), 9912-21.
33. Chen, Yiping#; Xianyu, Yunlei#; Wang, Yu; Zhang, Xiaoqing; Cha, Ruitao; Sun, Jiashu*; Jiang, Xingyu*; One-Step Detection of Pathogen and Virus Combining Magnetic Relaxation Switching and Magnetic Separation. ACS Nano 2015, 9 (3), 3184-91.
32. Zhang, Yi; Sun, Jiashu*; Zou, Yu; Chen, Wenen; Zhang, Wei*; Xi, Jianzhong Jeff; Jiang, Xingyu*; Barcoded Microchips for Biomolecular Assays. Analytical Chemistry 2015, 87 (2), 900-6.
31. Wang, Jidong#, Lu, Wenjing#, Tang, Chuanhao#; Liu, Yi#; Sun, Jiashu*, Mu, Xuan; Zhang, Lin; Dai, Bo; Li, Xiaoyan; Zhuo, Hailong; Jiang, Xingyu; Label-Free Isolation and mRNA Detection of Circulating Tumor Cells from Patients with Metastatic Lung Cancer for Disease Diagnosis and Monitoring Therapeutic Efficacy. Analytical Chemistry 2015, 87 (23), 11893-900.
30. He, Sha#; Zhang, Yi#; Wang, Pei; Xu, Xingzhi; Zhu, Kui; Pan, Wenying; Liu, Wenwen; Cai, Kaiyong*; Sun, Jiashu*; Zhang, Wei; Jiang, Xingyu*; Multiplexed Microfluidic Blotting of Proteins and Nucleic Acids by Parallel, Serpentine Microchannels. Lab on a Chip 2015, 15 (1), 105-12, Inside Back Cover, Hot Articles.
29. Liu, Chao; Hu, Guqing*; Jiang, Xingyu; Sun, Jiashu*; Inertial Focusing of Spherical Particles in Rectangular Microchannels over a Wide Range of Reynolds Numbers. Lab on a Chip 2015. 15 (4), 1168-77.
28. Li, Mengmeng#; Wang, Shiwen#; Jiang, Jia#; Sun, Jiashu*; Li, Yuzhuo; Huang, Deyong; Long, Yun-Ze; Zheng, Wenfu; Chen, Shiyi*; Jiang, Xingyu*; Surface Modification of Nano Silica on Ligament Advanced Reinforcement System for Accelerated Bone Formation: Primary Human Osteoblasts Testing in vitro and Animal Testing in vivo. Nanoscale 2015, 7(17), 8071-5.
27. Feng, Qiang#; Zhang, Lu#; Liu, Chao#; Li, Xuanyu; Hu, Guoqing; Sun, Jiashu*; Jiang, Xingyu*; Microfluidic Based High Throughput Synthesis of Lipid-Polymer Hybrid Nanoparticles with Tunable Diameters. Biomicrofluidics 2015, 9, 052604.
2014
26. Sun, Jiashu; Xianyu, Yunlei; Jiang, Xingyu*; Point-of-Care Biochemical Assays Using Gold Nanoparticle-Implemented Microfluidics. Chemical Society Reviews 2014, 43 (17), 6239-6253.
25. Zhang, Yi#; Zhang, Lu#; Sun, Jiashu*; Liu, Yulei; Ma, Xingjie; Cui, Shangjin; Ma, Liying; Xi, Jianzhong Jeff; Jiang, Xingyu*; Point-of-Care Multiplexed Assays of Nucleic Acids Using Microcapillary-based Loop-Mediated Isothermal Amplification. Analytical Chemistry 2014, 86 (14), 7057-62.
24. Zhang, Lu#; Zhang, Yi#; Wang, Chunyan#; Feng, Qiang; Fan, Fei; Zhang, Guojun; Kang, Xixiong; Qin, Xuzhen; Sun, Jiashu*; Li, Yinghui*; Jiang, Xingyu*; Integrated Microcapillary for Sample-to-Answer Nucleic Acid Pretreatment, Amplification, and Detection. Analytical Chemistry 2014, 86 (20), 10461-6.
23. Wang, Shiwen#; Chen, Wei#; He, Sha; Zhao, Qilong; Li, Xiaohong*; Sun, Jiashu*; Jiang, Xingyu*; Mesosilica-Coated Ultrafine Fibers for Highly Efficient Laccase Encapsulation. Nanoscale 2014, 6 (12), 6468-72.
22. Wang, Jidong#; Chen, Wenwen#; Sun, Jiashu*; Liu, Chao; Yin, Qifang; Zhang, Lu; Xianyu, Yunlei; Shi, Xinghua; Hu, Guqing*; Jiang, Xingyu*; A Microfluidic Tubing Method and its Application for Controlled Synthesis of Polymeric Nanoparticles. Lab on a Chip 2014, 14 (10), 1673-7. Lab on a Chip 2014 Most Accessed Articles.
21. Lu, Wenjing; Sun, Jiashu*; Jiang, Xingyu*; Recent Advances in Electrospinning Technology and Biomedical Applications of Electrospun Fibers. Journal of Materials Chemistry B 2014, 2 (17), 2369-80.
20. Chen, Xiaodong; Xue, Chundong; Zhang, Li; Hu, Guqing*; Jiang, Xingyu; Sun, Jiashu*; Inertial Migration of Deformable Droplets in a Microchannel. Physics of Fluids 2014, 26, 112003.
19. Xianyu, Yunlei; Wang, Zhuo; Sun, Jiashu; Wang, Xuefei; Jiang, Xingyu*; Colorimetric Logic Gates through Molecular Recognition and Plasmonic Nanoparticles. Small 2014, 10 (23), 4838-8.
2013
18. Xianyu, Yunlei; Sun, Jiashu*; Li, Yixuan; Tian, Yue; Wang, Zhuo*; Jiang, Xingyu*; An Ultrasensitive, Non-Enzymatic Glucose Assay via Gold Nanorod-Assisted Generation of Silver Nanoparticles. Nanoscale 2013, 5 (14), 6303-6.
17. Sun, Jiashu#; Liu, Chao#; Li, Mengmeng#; Wang, Jidong; Xianyu, Yunlei; Hu, Guoqing*; Jiang, Xingyu*; Size-based Hydrodynamic Rare Tumor Cell Separation in Curved Microfluidic Channels. Biomicrofluidics 2013, 7 (1), 011802, ESI Highly Cited Papers (last 10 years).
16. Sun, Jiashu#; Xianyu, Yunlei#; Li, Mengmeng#; Liu, Wenwen; Zhang, Lu; Liu, Dingbin; Liu, Chao; Hu, Guoqing; Jiang, Xingyu*; A Microfluidic Origami Chip for Synthesis of Functionalized Polymeric Nanoparticles. Nanoscale 2013, 5 (12), 5262-5.
15. Sun, Jiashu, Kang, Yuejun*; Boczko, Erik; Jiang, Xingyu*; A Microfluidic Cell Size/Density Sensor by Resistive Pulse Detection. Electroanalysis 2013, 25, 1023-1028.
14. Li, Mengmeng#; Liu, Wenwen#; Sun, Jiashu*; Xianyu, Yunlei; Wang, Jidong; Zhang, Wei; Zheng, Wenfu; Huang, Dayong; Di, Shiyu; Long, Yunze*; Jiang, Xingyu*; Culturing Primary Human Osteoblasts on Electrospun Poly(lactic-co-glycolic acid) and Poly(lactic-co-glycolic acid)/Nanohydroxyapatite Scaffolds for Bone Tissue Engineering. ACS Applied Materials and Interfaces 2013, 5 (13), 5921-6.
13. Jin, Yu; Wang, Nuoxin; Yuan, Bo; Sun, Jiashu; Li, Mengmeng; Zheng, Wenfu; Zhang, Wei; Jiang, Xingyu*; Stress-Induced Self-assembly of Complex Three Dimensional Structures by Elastic Membranes. Small 2013, 9 (14), 2410-4.
12. Xianyu, Yunlei; Zhu, Kui; Chen, Wenwen; Wang, Xuefei; Zhao, Hongmei; Sun, Jiashu; Wang, Zhuo*; Jiang, Xingyu*; Enzymatic Assay for Cu(II) with Horseradish Peroxidase and its Application in Colorimetric Logic Gate. Analytical Chemistry 2013, 85 (15), 7029-32.
11. Mu, Xuan#; Zheng, Wenfu#; Sun, Jiashu; Zhang, Wei; Jiang, Xingyu*; Microfluidics for Manipulating Cells. Small 2013, 9 (1), 9-21.
2012
10. Sun, Jiashu, Gao, Yandong, Isaacs, Richard J.; Boelte, Kimberly C.; Lin, P. Charles; Boczko, Erik M.*; Li, Deyu*; Simultaneous On-Chip DC Dielectrophoretic Cell Separation and Quantitative Separation Performance Characterization. Analytical Chemistry 2012, 84 (4), 2017-2024.
9. Sun, Jiashu#,*; Li, Mengmeng#; Liu, Chao; Zhang, Yi; Liu, Dingbin; Liu, Wenwen; Hu, Guoqing*; Jiang, Xingyu*; Double Spiral Microchannel for Label-free Tumor Cell Separation and Enrichment. Lab on a Chip 2012, 12 (20), 3952-60.
8. Yuan, Bo#; Jin, Yu#; Sun, Yi; Wang, Dong; Sun, Jiashu, Wang, Zhuo; Zhang, Wei*; Jiang, Xingyu*; A Strategy for Depositing Different Types of Cells in Three Dimensions to Mimic Tubular Structures in Tissues. Advanced Materials 2012, 24 (7), 890-896.
7. Liu, Dingbin; Wang, Shouju; Swierczewska, Magdalena; Huang, Xinglu; Bhirde, Ashwinkumar A.; Sun, Jiashu; Wang, Zhuo; Yang, Ming*; Jiang, Xingyu*; Chen, Xiaoyuan*; Highly Robust, Recyclable Displacement Assay for Mercuric Ions in Aqueous Solutions and Living Cells. ACS Nano 2012, 6 (12), 10999-1008.
6. Liu, Dingbin; Chen, Wenwen; Tian, Yue; He, Sha; Zheng, Wenfu; Sun, Jiashu, Wang, Zhuo*; Jiang, Xingyu*; A Highly Sensitive Gold-Nanoparticle-based Assay for Acetylcholinesterase in Cerebrospinal Fluid of Transgenic Mice with Alzheimer's Disease. Advanced Healthcare Materials 2012, 1 (1), 90-5.
5. Gao, Yandong; Sun, Jiashu; Lin, Wan-Hsin, Webb, Donna J.; Li, Deyu*; A Compact Microfluidic Gradient Generator using Passive Pumping. Microfluidics and Nanofluidics 2012, 12 (6), 887-895.
2009-2011
4. Li, Mengmeng; Long, Yunze*; Yang, Dayong; Sun, Jiashu; Yin, Hongxing; Zhao, Zhili; Kong, Wenhao; Jiang, Xingyu*; Fan, Zhiyong; Fabrication of One Dimensional Superfine Polymer Fibers by Double-Spinning. Journal of Materials Chemistry 2011, 21 (35), 13159-13162.
3. Sun, Jiashu; Stowers, Chris C.; Boczko, Erik M.; Li, Deyu*; Measurement of the Volume Growth Rate of Single Budding Yeast with the MOSFET-based Microfluidic Coulter Counter. Lab on a Chip 2010, 10 (21), 2986-93.
2. Sun, Jiashu; Vajandar, Saumitra K.; Xu, Dongyan; Kang, Yuejun; Hu, Guoqing*; Li, Dongqing; Li, Deyu*, Experimental Characterization of Electrical Current Leakage in Poly(dimethylsiloxane) Microfluidic Devices. Microfluidics and Nanofluidics 2009, 6 (5), 589-598.
1. Vajandar, Saumitra K.; Xu, Dongyan; Sun, Jiashu; Markov, Dmitry A.; Hofmeister, William. H.; Li, Deyu*; Field-Effect Control of Electroosmotic Pumping Using Porous Silicon-Silicon Nitride Membranes. Journal of Microelectromechanical Systems 2009, 18 (6), 1173-1183.
